CERAPP: Collaborative Estrogen Receptor Activity Prediction Project
نویسندگان
چکیده
منابع مشابه
CERAPP: Collaborative Estrogen Receptor Activity Prediction Project
BACKGROUND Humans are exposed to thousands of man-made chemicals in the environment. Some chemicals mimic natural endocrine hormones and, thus, have the potential to be endocrine disruptors. Most of these chemicals have never been tested for their ability to interact with the estrogen receptor (ER). Risk assessors need tools to prioritize chemicals for evaluation in costly in vivo tests, for in...
متن کاملEstrogen Receptor Activity
Natural estrogens modulate the activity of target cells by binding at least two intranuclear receptors. ERα and ERβ belong to a large family of structurally related transcription factors that are well conserved from the evolutionary and functional points of view. The considerable progress made recently in comprehending ER structure (figs. 6–1 and 6–2) and mechanism of action (fig. 6–2) provides...
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In human breast cancer, estrogen receptor (ER) status of the tumor has prognostic and therapeutic significance. However, facilities to study ER are not widely available to us. We postulated that if there is a correlation between histologic grade and ER status of invasive ductal carcinoma (IDC), it may help predict the ER status of the tumor. Of 8 4 cases of breast carcinoma referred to the ...
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Abstract Introduction: Estrogen receptor-positive (ER-positive) breast cancer is a subgroup of breast tumors that is more likely to respond to hormone therapy. ER-positive and ER- negative breast cancers tend to show different patterns of metastasis because of different signaling cascade and genes that are activated by estrogen response. Genetic factors can contribute to high rates of metastas...
متن کاملBioinformatics-Based Prediction of FUT8 as a Therapeutic Target in Estrogen Receptor-Positive Breast Cancer
Abstract Introduction: Estrogen receptor-positive (ER-positive) breast cancer is a subgroup of breast tumors that is more likely to respond to hormone therapy. ER-positive and ER- negative breast cancers tend to show different patterns of metastasis because of different signaling cascade and genes that are activated by estrogen response. Genetic factors can contribute to high rates of metastas...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2016
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.1510267